SAT-274 The Optimal Dosage of Vitamin D Supplement for Vitamin D Deficiency in Korean Children and Adolescents

Abstract

Purpose: Vitamin D deficiency (VDD) is very common nowadays in children as well as in adults, probably due to decreased exposure to sunlight. In Korea, the prevalence of VDD was 47% in teenage boys and 65% in teenage girls. However, the optimal dosage regimen for correcting deficiency is unknown. We investigate the change of serum 25(OH) vitamin D concentration according to the treatment dosage and duration in VDD. Methods: Data was collected from 1797 children and adolescents aged 0 to 16 year between August in 2017 and July in 2018, retrospectively. They were divided to 3 groups (deficiency, insufficiency, sufficiency) according to their serum 25(OH) vitamin D concentrations (less than 20, between 20 and 30, more than 30 ng/mL, respectively). There were 3 subgroups (poor, moderate, good) according the daily increase (DI) of the serum 25(OH) vitamin D concentration (less than 0.3, between 0.3 and 0.6, more than 0.6 ng/mL/day, respectively) after 4 to 6 week oral administration of 25(OH) vitamin D in children and adolescents with vitamin D deficiency. Results: The serum 25(OH) vitamin D concentration showed the correlation with age (p=0.000), gender (p=0.000), weight standard deviation score (SDS) (p=0.008) and body mass index (BMI) SDS (p=0.000). And the serum 25(OH) vitamin D concentration showed seasonal variation in children over 2 years of age and adolescents (p=0.000). There was a significant correlation between serum 25(OH) vitamin D concentration and DI (p=0.021). In VDD patients treated with vitamin D, DI were not correlated with age, sex, weight SDS and BMI SDS. Conclusions: The prevalence of VDD increased in female, older age, overweight and winter in Korea and the response to treatment was higher in patient with lower serum 25(OH) D concentration. It may be appropriate to take an oral 25(OH) Vitamin D with 2000 IU/day for 6 weeks in Korean children and adolescents with VDD.