Abstract
Patients with autosomal dominant polycystic kidney disease (ADPKD) have a high incidence rate of hypertension and cardiovascular disease. Endothelial dysfunction (ED) has been reported in some patient ADPKD cohorts although published studies have been confounded by the inclusion of patients with significant chronic kidney disease (CKD), hypertension, anti-hypertensive drugs and other co-morbidities (age, smoking, high BMI). The major aim of this study was to test the hypothesis that ED was present in normotensive ADPKD patients with early disease (≥60ml/min/1.73m2) without confounding risk factors by assessing vascular function, serum and urine biomarkers in a single centre prospective study.
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