Abstract
Furosemide, the most commonly used diuretic, has been proposed to improve renal medullary oxygenation. However, studies in patients with acute kidney injury (AKI) demonstrated that treatment with high doses of furosemide worsens renal function. In experimental sepsis, the rapid development of renal medullary hypoxia precedes the development of AKI and may contribute to its pathogenesis. We therefore investigated whether inhibiting active sodium transport and oxygen consumption in the medullary thick ascending limb with low-dose furosemide attenuates the medullary hypoxia in experimental septic AKI.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
