Abstract
The loss of permselectivity resulting in proteinuria is a critical step during kidney disease progression. The luminal surface layer of the glomerular capillary endothelium (ESL) consists of a glycocalyx and an endothelial cell coat, which together form a stagnant mucosal layer hindering leakage of macromolecules such as albumin from blood to urine. We have investigated the composition and possible role for the ESL in glomerular kidney disease.
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