Abstract
Autosomal dominant polycystic kidney disease (ADPKD) is the most common genetic cause of end stage renal disease (ESRD). Studies in the 1990s showed that levels of two glycosphingolipids—glucosylceramide (GL-1) and lactosylceramide—were higher in the kidneys of PKD patients and in mouse models of PKD than in those of healthy controls.
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