Abstract
SASOP Biological Psychiatry Congress 2013 Abstracts
Highlights
Electroconvulsive therapy (ECT) involves the administration of an electrical current to the brain in order to producing a tonic-clonic seizure
This presentation focuses on the prevalence and correlates of psychiatric comorbidity among patients with heroin dependence admitted to the Opioid Detoxification Unit at Stikland Hospital, Western Cape Province, South Africa
In this study we investigated the effects of prenatal methylmercury exposure (2.5 mg/l in drinking water from GND 1) on the trace element status in the brain of adolescent offspring at postnatal day (PND) 28
Summary
HIV-induced cognitive impairment is among the most common neurological disorders associated with AIDS. Despite the introduction of highly active antiretroviral therapy (HAART), continuous neuronal cell death remains a problem for AIDS patients. Studies have shown that transregulatory protein (Tat) induces oxidative stress in neurons, suggesting that HAART alone is not enough in addressing the complex nature of HIV and an alternative or supplementary therapy is needed. There is limited literature on the role of antiretroviral drugs on Tat-induced neurotoxicity. To investigate (i) the role of HAART on Tat-induced oxidative stress in hippocampal neurons and (ii) whether. Some animals will receive an intraperitoneal (i.p) injection of NACA (250 mg/kg body weight) or saline (10 μl) while HAART (10.5 mg/kg) will be administered by oral gavage. Flow cytometry detection of active caspase-3 has shown a low percentage of active caspase-3 on Tat + saline animals. Tat protein does not cause neuron apoptosis. This suggests that Tat may cause neuronal dysfunction rather than neuronal death
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