Sasa quelpaertensis leaf extract suppresses inflammation in DSS‐induced colitis in vivo (830.7)

Abstract

Sasa quelpaertensis Nakai is a species of bamboo grasses grown in Mt.Halla on Jeju Island in South Korea. Sasa leaves have been suggested to have anti‐diabetic, anti‐cancer, and anti‐inflammatory effects. Inflammatory bowel disease (IBD) is a disease characterized by chronic inflammatory disorders of the gastrointestinal tract. The aim of this study is to investigate the possible protective role of Sasa quelpaertensis leaf extract (SQE) on dextran sodium sulphate (DSS)‐induced colitis in mice model. We found that SQE attenuated the severity of IBD assessed by disease activity index (DAI) score, shrinkage of colon length, and histopathological changes. SQE also significantly suppressed the DSS‐induced serum inflammatory cytokines including TNF‐α, IL‐1β and IL‐6. Furthermore, SQE down‐regulates the expression of TNF‐ α, COX‐2, iNOS, NF‐kB, and PPARγ. Furthermore, SQE down‐regulated ERK1/2 phosphorylation, but not p38 or JNK. These results suggest that SQE may a protective role in gut inflammation including IBD via regulation of inflammatory mediators and inflammation‐mediated signal pathway.Grant Funding Source: Support by Rural Development Administration (# PJ009777) & brain korea 21 plus (# 22A20130012143)