Abstract
Background: Explore the cause of rapid advancing nature of double mutant strain in Indian Population especially in Northern Province and to access the deterioration of the patient’s condition from day 1 of admission to rapid decline in oxygen saturation with gross lung involvement noticed in CT Chest reports. Methods: The study was conducted in COVID 19 Ward and ICU at a tertiary care hospital in Gurgaon. A total of 60 patients were selected who were RT-PCR positive, all the patients were evaluated with continuous vitals monitoring and treatment. Results: From 60 patients, 35 patients showed rapid deterioration with fluctuating SpO2 and significant lung changes in CT chest whereas rest of 25 patients were maintaining SpO2 at 96% in room air. These sick patients were found to be falling in the young and middle age population who were non vaccinated and some had comorbidities as well on irregular medication. Conclusion: Our study aims to focus on the symptomatology and progress of the virus causing significant lung parenchymal involvement encountered specifically in the younger populations, most likely due to the undergoing genetic mutation of the virus thereby increasing transmissibility and virulence responsible for rise in number of mortality rates. Keywords: B.1.617 lineage; CORADS; mutant strain; SARS- CoV-2; virulence.
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