Abstract
Vaccines against COVID-19 (and its emerging variants) are an essential global intervention to control the current pandemic situation. Anaphylactic reactions have been reported after SARS-CoV2 RNA vaccines. Anaphylaxis is defined as a severe life-threatening generalized or systemic hypersensitivity reaction. This risk is estimated at 1/1,000,000 in the context of vaccine safety surveillance programs. The COVID-19 vaccination is rolling-out vastly in different courtiers and surveillance programs are key to monitor severe adverse reactions, such as anaphylaxis. Anaphylaxis due to vaccine is extremely rare and specific cases should receive individualized investigation and care. The here presented recommendations and follow-up from the French allergy community and the Montpellier WHO Collaborating Center in order to support the vaccination program and intends to support to healthcare professionals in their daily basis.
Highlights
Vaccines against COVID-19 are an essential global intervention to control the current pandemic situation
The UK issued an advisory statement which listed prior anaphylaxis to a vaccine, medication, or food as a contraindication [7]. This recommendation was not followed by USA FDA nor the US Centers for Disease Control and Prevention (CDC), there is a recommendation of 15 min observation following the vaccination [2]. These recommendations generated a fear of receiving the mRNA COVID-19 vaccine in the population and was the reason for many inquiries from health professionals dealing with COVID-19 and vaccination programs
With more than a quarter of the general population suffering from allergies and soon half according to the World Health Organization (WHO), the food and pharmaceutical industries in general and vaccines in particular are increasingly faced with the risk of allergic manifestations to their products, not detected during the development phase, sometimes documented and confirmed but far from it
Summary
Essential to Control the COVID-19 Pandemic tutional affiliations. As of 13 April 2021, a total of 135,057,587 cases of coronavirus disease 2019 (COVID19) and 2,919,932 associated deaths were reported globally by the World Health Organization (WHO) [1]. The UK issued an advisory statement which listed prior anaphylaxis to a vaccine, medication, or food as a contraindication [7] This recommendation was not followed by USA FDA nor the US Centers for Disease Control and Prevention (CDC), there is a recommendation of 15 min observation following the vaccination [2]. These recommendations generated a fear of receiving the mRNA COVID-19 vaccine in the population and was the reason for many inquiries from health professionals dealing with COVID-19 and vaccination programs. History of allergy to other substances, such as hymenoptera venom, inhalant allergens, foods, regardless of their severity, are not a contraindication to COVID-19 vaccine”
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