Sars-Cov-2 Spike protein function prediction using a convolutional neural network ensemble

Abstract

Introduction: SARS-CoV-2 has become a worldwide pandemic that affects all aspects of life; therefore, numerous organizations and open exploration foundations focus their efforts on research for viable therapeutics. Given past experiences and involvement in SARS, the essential focus has been the Spike protein, considered as the perfect objective for COVID-19 immunotherapies. Most of the vaccines being developed target the spike proteins because this protein covers the virus and helps it invade human cells. Methods: Applications of deep neural network is a quickly expanding field now reaching many areas including proteomics. Results: To be precise, convolutional neural networks have been used for identifying the functional role of amino acid sequences, because of its ability to give nearly accurate results for multi-label classification problems. Here we present a modified convolutional deep learning model that can identify if a given amino acid sequence is a spike protein or not based on the length of the sequence and the function of the protein, that will be done with a short execution time and a relatively small error rate.
 Conclusion: CNN is an efficient tool at supervised multilabel classification problems