SARS-CoV-2 infection and COVID‒19 in Gaucher disease: indications for vaccination

László Maródi

doi:10.1556/650.2021.32272

Abstract

At the start of the pandemic caused by the novel coronavirus (SARS-CoV-2), the Gaucher disease community anticipated that infection with this emerging viral pathogen would be associated with high morbidity and mortality in individuals with this chronic metabolic disorder. Surprisingly, however, preliminary studies suggest that Gaucher disease does not confer a higher risk of severe, life-threatening effects of SARS-CoV-2 infection, and no severe cases have been reported in large cohorts of patients from the United States, Europe and Israel. It is thought that the accumulation of glucocerebroside in the cells of Gaucher patients may promote immune tolerance rather than inflammation on exposure to SARS-CoV-2. We review here the current concepts of Gaucher disease and SARS-CoV-2 infection, focusing particularly on general prevention and vaccination. We also discuss the susceptibility to COVID-19 of patients with inborn errors of type 1 interferon (IFNα and IFNω) immunity. Orv Hetil. 2021; 162(24): 938-942.

Highlights

At the start of the pandemic caused by the novel coronavirus (SARS-CoV-2), the Gaucher disease community anticipated that infection with this emerging viral pathogen would be associated with high morbidity and mortality in individuals with this chronic metabolic disorder
Preliminary studies suggest that Gaucher disease does not confer a higher risk of severe, life-threatening effects of SARS-CoV-2 infection, and no severe cases have been reported in large cohorts of patients from the United States, Europe and Israel
It is thought that the accumulation of glucocerebroside in the cells of Gaucher patients may promote immune tolerance rather than inflammation on exposure to SARS-CoV-2

Summary

Introduction

At the start of the pandemic caused by the novel coronavirus (SARS-CoV-2), the Gaucher disease community anticipated that infection with this emerging viral pathogen would be associated with high morbidity and mortality in individuals with this chronic metabolic disorder. [SARS-CoV-2 infection and COVID-19 in Gaucher disease: indications for vaccination]. A COVID–19 (coronavirus disease 2019; koronavírusbetegség 2019 ) – amelynek kórokozója a SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2; súlyos akut légúti szindrómát okozó koronavírus-2) – 2019 óta ismert, először Kínában (Hupei tartomány, Wuhan város) felbukkant, majd hamarosan az egész világon elterjedt, jelentős mortalitású fertőző betegség [1].

Results

Conclusion