Abstract
We analyzed size of severe acute respiratory coronavirus 2 (SARS-CoV-2) aerosol particles shed by experimentally infected cynomolgus monkeys. Most exhaled particles were small, and virus was mainly released early during infection. By postinfection day 6, no virus was detected in breath, but air in the isolator contained large quantities of aerosolized virus.
Highlights
We analyzed size of severe acute respiratory coronavirus 2 (SARS-CoV-2) aerosol particles shed by experimentally infected cynomolgus monkeys
A recent study showed that coronavirus disease (COVID-19) patients exhaled millions of SARS-CoV-2 particles during early infection stages [5]
In exhaled breath of inoculated monkeys and in air in the isolator, viral RNA was detected in all size bins, 0.65–2.1 mm, 2.1–4.7 mm, and >4.7 mm, at postinfection days 2 and 4; most were concentrated in the 2.1–4.7-mm bin (Figure, panels B, D; Appendix Tables 1, 2)
Summary
We analyzed size of severe acute respiratory coronavirus 2 (SARS-CoV-2) aerosol particles shed by experimentally infected cynomolgus monkeys. By postinfection day 6, no virus was detected in breath, but air in the isolator contained large quantities of aerosolized virus. A recent study showed that coronavirus disease (COVID-19) patients exhaled millions of SARS-CoV-2 particles during early infection stages [5].
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