Abstract

SARS Coronaviruses and Highly Pathogenic Influenza Viruses: Safety and Occupational Health for Laboratory Workers

Highlights

  • Throughout this manual, references are made to the relative hazards of infective microorganisms by risk group (WHO Risk Groups 1, 2, 3 and 4)

  • On the basis of the information ascertained during the risk assessment, a biosafety level can be assigned to the planned work, appropriate personal protective equipment selected, and standard operating procedures (SOPs) incorporating other safety interventions developed to ensure the safest possible conduct of the work

  • For the purposes of this manual, the guidance and recommendations given as minimum requirements pertaining to laboratories of all biosafety levels are directed at microorganisms in Risk Groups 1–4

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Summary

Introduction

Throughout this manual, references are made to the relative hazards of infective microorganisms by risk group (WHO Risk Groups 1, 2, 3 and 4) This risk group classification is to be used for laboratory work only. Risk Group 1 (no or low individual and community risk) A microorganism that is unlikely to cause human or animal disease. Risk Group 2 (moderate individual risk, low community risk) A pathogen that can cause human or animal disease but is unlikely to be a serious hazard to laboratory workers, the community, livestock or the environment. Laboratory exposures may cause serious infection, but effective treatment and preventive measures are available and the risk of spread of infection is limited. Risk Group 3 (high individual risk, low community risk) A pathogen that usually causes serious human or animal disease but does not ordinarily spread from one infected individual to another. Countries (regions) should draw up a national (regional) classification of microorganisms, by risk group, taking into account:

Maximum Dangerous pathogen As Level 3 plus
GENERAL PRINCIPLES
Microbiological risk assessment
Basic laboratories – Biosafety Levels 1 and 2
BASIC LABORATORIES – BIOSAFETY LEVELS 1 AND 2
The containment laboratory – Biosafety Level 3
THE CONTAINMENT LABORATORY – BIOSAFETY LEVEL 3
Front of card
The maximum containment laboratory – Biosafety Level 4
Laboratory animal facilities
LABORATORY ANIMAL FACILITIES
Laboratory biosecurity concepts
10. Biological safety cabinets
E B A front view room air potentially contaminated air HEPA-filtered air
11. Safety equipment
11. SAFETY EQUIPMENT
12. Laboratory techniques
12. LABORATORY TECHNIQUES
13. Contingency plans and emergency procedures
13. CONTINGENCY PLANS AND EMERGENCY PROCEDURES
14. Disinfection and sterilization
14. DISINFECTION AND STERILIZATION
15. Introduction to the transport of infectious substances
15. INTRODUCTION
16. Biosafety and recombinant DNA technology
17. Hazardous chemicals
17. HAZARDOUS CHEMICALS
18. Additional laboratory hazards
18. ADDITIONAL LABORATORY HAZARDS
Radioactive waste area
19. The biosafety officer and biosafety committee
20. Safety for support staff
21. Training programmes
21. TRAINING PROGRAMMES
22. Safety checklist
22. SAFETY CHECKLIST
Findings
PART IX
Full Text
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