Abstract
Many bioactive materials have been isolated from marine microorganisms, including alkaloids, peptides, lipids, mycosporine-like amino acids, glycosides, and isoprenoids. Some of these compounds have great potential in the cosmetic industry due to their photo-protective, anti-aging, and anti-oxidant activities. In this study, sarmentosamide (1) was isolated from marine-derived Streptomyces sp. APmarine042, after which its capacity to decrease skin aging was examined in-vitro. Sarmentosamide (1) was found to significantly reduce UVB-induced matrix metalloproteinase-1 (MMP-1) expression in normal human dermal fibroblasts (NHDFs) by inhibiting the extracellular signal-regulated kinase (ERK) and the c-Jun N-terminal kinase (JNK) phosphorylation, which are regulatory pathways upstream of MMP-1 transcription. Additionally, we confirmed that sarmentosamide (1) decreased tumor necrosis factor-alpha (TNF-α), induced MMP-1 secretion in NHDFs, and exhibited free-radical scavenging activity, as demonstrated by 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay. Therefore, our study suggests that sarmentosamide (1) could be a promising anti-aging agent that acts via the downregulation of MMP-1 expression.
Highlights
IntroductionSkin aging is induced by two main processes, which result from intrinsic and extrinsic factors
Skin aging is induced by two main processes, which result from intrinsic and extrinsic factors.Extrinsic aging is primarily caused by exposure to environmental factors such as air pollution [1]and ultraviolet (UV) radiation [2]
Could be a promising anti-aging agent that acts via the downregulation of matrix metalloproteinase-1 (MMP-1) expression
Summary
Skin aging is induced by two main processes, which result from intrinsic and extrinsic factors. Previous studies have reported that UVB radiation induces ROS (reactive oxygen species) production and leads to the activation of intracellular signaling pathways and transcription factors production and leads to the activation of intracellular signaling pathways and transcription factors (e.g., AP-1, NF-κB) [9]. These transcription factors are regulated by mitogen-activated protein kinases (MAPKs), which induce MMP-1 and proinflammatory cytokines. APmarine extract, and its chemical structure was identified via NMR analyses as sarmentosamide (1), a compound with a hexadienamide moiety [10]. We examined the antioxidant activity of sarmentosamide (1) via a 2,2-diphenyl-1-picrylhydrazyl we examined the antioxidant activity of sarmentosamide (1) via a 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging assay
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