Sargassum polycystum juice alleviates the syndrome on the type 2 diabetic rats

Abstract

Weight loss, polyphagia, polyuria, and polydipsia appear frequently on type 2 diabetics. This syndrome can be corrected by hypoglycemic agents where it can source from synthetic and natural compounds. Sargassum polycystum contains many bioactive compounds that it contribute probably to improve this syndrome. Juicing is one of techniques to separate quickly and easily the bioactive solution from their matrices. This study aimed to evaluate S. polycystum juice for the improvement of type 2 diabetic rat syndrome. This study was conducted at the Pharmacology Laboratory, Faculty of Medicine, Universitas Brawijaya. There were seven groups in this study: negative control, negative control + 1 mL juice, diabetes control, diabetes + drug, diabetic rats + 0.5 mL juice, diabetic rats + 1 mL juice, and diabetic rats + 1.5 mL juice. This study used metformin as an oral hypoglycemic drug. Observations of changes in blood glucose and improvement of diabetes syndrome were carried out at the end of the study. The diabetic rats showed hyperglycemia and diabetes syndrome, while administration of S. polycystum juice in diabetic rats improved blood sugar levels and diabetes syndrome, but these results were not as optimal as oral hypoglycemic drugs. This study concluded that administration of S. polycystum juice could reduce hyperglycemia and improve diabetes syndrome in type 2 diabetic rats.