Abstract
Background: SARC-F and Mini Sarcopenia Risk Assessment (MSRA) questionnaires have been proposed as screening tools to identify patients at risk of sarcopenia. The aim of this study is to test the use of SARC-F and MSRA, alone and combined, as a pre-screening tool for sarcopenia in geriatric inpatients. Methods: 152 subjects, 94 men and 58 women, aged 70 to 94, underwent muscle mass evaluation by dual energy X-ray absorptiometry (DXA), muscle strength evaluation by handgrip, and completed the MSRA, SARC-F and Activity of daily living (ADL) questionnaires. Results: 66 subjects (43.4%) were classified as sarcopenic according to the European Working Group on Sarcopenia in Older People 2 (EWGSOP2) criteria. The 7-item SARC-F and MRSA and 5-item MSRA showed an area under the curve (AUC) of 0.666 (95% confidence interval (CI): 0.542–0.789), 0.730 (95% CI: 0.617–0.842) and 0.710 (95% CI: 0.593–0.827), respectively. The optimal cut-off points for sarcopenia detection were determined for each questionnaire using the Youden index method. The newly calculated cut-off points were ≤25 and ≤40 for MSRA 7- and 5-items, respectively. The ideal cut-off for the SARC-F was a score ≥3. Applying this new cut-off in our study population, sensitivity and specificity of the 7-item MSRA were 0.757 and 0.651, and 0.688 and 0.679 for the 5-item MSRA, respectively. Sensitivity and specificity of SARC-F were 0.524 and 0.765, respectively. The combined use of the 7-item SARC-F and MSRA improved the accuracy in sarcopenia diagnosis, with a specificity and sensitivity of 1.00 and 0.636. Conclusion: 7-item SARC-F and MSRA may be co-administered in hospital wards as an easy, feasible, first-line tool to identify sarcopenic subjects.
Highlights
Introduction published maps and institutional affilSarcopenia is a clinical phenomenon characterized by progressive and generalized loss of skeletal muscle mass and strength, with a risk of unfavorable health consequences such as worsening disability, reduction of functional autonomy, increased risk of hospitalization, low quality of life and increased mortality [1,2,3,4,5] Identifying older adults with sarcopenia in different clinical settings is crucial, in order to put a brake on progression towards disability and other adverse health outcomes
94 men and 58 women with mean age of 81.13 ± 5.53 years were involved in the study: 66 out of 152 subjects, 43.4% of the study population, were classified as sarcopenic according to the EWGSOP2 criteria
Scores in the 5- and 7-item Mini Sarcopenia Risk Assessment (MSRA), SARC-F as well as BMI were significantly lower in sarcopenic subjects
Summary
Introduction published maps and institutional affilSarcopenia is a clinical phenomenon characterized by progressive and generalized loss of skeletal muscle mass and strength, with a risk of unfavorable health consequences such as worsening disability, reduction of functional autonomy, increased risk of hospitalization, low quality of life and increased mortality [1,2,3,4,5] Identifying older adults with sarcopenia in different clinical settings is crucial, in order to put a brake on progression towards disability and other adverse health outcomes. Muscle mass quantification involves a wide range of techniques, such as dual energy X-ray absorptiometry (DXA), computer tomography and magnetic resonance, which, are difficult to access, especially in primary care settings [5]. SARC-F and Mini Sarcopenia Risk Assessment (MSRA) questionnaires have been proposed as screening tools to identify patients at risk of sarcopenia. The aim of this study is to test the use of SARC-F and MSRA, alone and combined, as a pre-screening tool for sarcopenia in geriatric inpatients. Methods: 152 subjects, 94 men and 58 women, aged 70 to 94, underwent muscle mass evaluation by dual energy X-ray absorptiometry (DXA), muscle strength evaluation by handgrip, and completed the MSRA, SARC-F and Activity of daily living (ADL) questionnaires
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