Abstract
Sarcopenia a recognised geriatric syndrome. This study aims to evaluate the prevalence of possible sarcopenia, sarcopenia and severe sarcopenia among older Chinese adults and to identify any associated factors for possible sarcopenia according to the updated diagnostic criteria of the Asian Working Group for Sarcopenia 2019 (AWGS 2019). We used data from the China Health and Retirement Longitudinal Study (CHARLS). The main outcome of this study was possible sarcopenia. Handgrip strength was measured via a dynamometer. The muscle mass was estimated by anthropometric measures. Physical performance was measured by 5-time chair stand test and gait speed test. A multivariate logistic regression model with stepwise method was employed to identify factors associated with possible sarcopenia. A total of 6172 participants aged 60–94 years were included. The prevalence of possible sarcopenia, sarcopenia and severe sarcopenia was 38.5%, 18.6%, and 8.0%, respectively. Age, rural area, falls, higher C-reactive protein (CRP), and chronic diseases (including hypertension, chronic lung diseases, heart disease, psychiatric disease and arthritis) were associated with a higher risk of possible sarcopenia. Conversely, alcohol consumption, higher gait speed and high levels of hemoglobin were associated with decreased risk of possible sarcopenia. However, the associations between possible sarcopenia with alcohol consumption, heart disease, psychiatric disease and hemoglobin were not significant after Bonferroni correction. Our study reported a relatively high prevalence of sarcopenia among older Chinese population, and identified a range of factors associated with sarcopenia. We also found rural elders are more vulnerable to sarcopenia than urban elders. Additionally, we discovered systemic inflammation might be one of the contributing factors between sarcopenia and related comorbidities. We believe the findings of this study would help to identify individuals at high risk of sarcopenia early and therefore implement the prevention and treatment strategies to reduce the disease burden in China.
Highlights
Sarcopenia, a progressive and generalized skeletal muscle disorder, is associated with an increased likelihood of adverse consequences such as falls, fractures, physical disability and mortality [1]
According to the updated diagnostic criteria of AWGS 2019, we found that the overall prevalence of possible sarcopenia, sarcopenia and severe sarcopenia in the study population, was 38.5%, 18.6%, and 8.0%, respectively and increased with age
We found the prevalence of possible sarcopenia obviously increased with age
Summary
Sarcopenia, a progressive and generalized skeletal muscle disorder, is associated with an increased likelihood of adverse consequences such as falls, fractures, physical disability and mortality [1]. The presence of sarcopenia increases the risk for hospitalization and the costs of care during hospitalization [2]. It is well known that China is one of the fastest aging countries in the world. Sarcopenina will have a significant impact on Chinese people in the near future. It is very important to know the prevalence of sarcopenia across China and identify the patients with possible sarcopenia and ulteriorly reduce the incidence of sarcopenia and severe sarcopenia in order to improve the health and quality of life for older people
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