Sarcopenia negatively affects hip structure analysis variables in a group of Lebanese postmenopausal women

Hayman Saddik,Rafic Baddoura,Rawad El Hage,Riad Nasr,Antonio Pinti,Eric Lespessailles,Abdel-Jalil Berro,Eric Watelain,Nathalie Al Rassy,Hechmi Toumi,Ibrahim Fayad

doi:10.1186/s12859-020-3353-9

Abstract

BackgroundThe current study’s purpose is to compare hip structural analysis variables in a group of postmenopausal women with sarcopenia and another group of postmenopausal women with normal skeletal muscle mass index. To do so, the current study included 8 postmenopausal women (whose ages ranged between 65 and 84 years) with sarcopenia and 60 age-matched controls (with normal skeletal muscle mass index (SMI)). Body composition and bone parameters were evaluated by dual-energy X-ray absorptiometry (DXA).ResultsWeight, lean mass, body mass index, femoral neck cross-sectional area (FN CSA), FN section modulus (Z), FN cross sectional moment of inertia (CSMI), intertrochanteric (IT) CSA, IT Z, IT CSMI, IT cortical thickness (CT), femoral shaft (FS) CSA, FS Z and FS CSMI were significantly greater (p < 0.05) in women with normal SMI compared to women with sarcopenia. In the whole population, SMI was positively associated with IT CSA, IT Z, IT CSMI, IT CT, FS CSA, FS Z, FS CSMI, FS CT but negatively correlated to IT buckling ratio (BR) and FS BR.ConclusionThe current study suggests that sarcopenia has a negative effect on hip bone strength indices in postmenopausal women.

Highlights

The current study’s purpose is to compare hip structural analysis variables in a group of postmenopausal women with sarcopenia and another group of postmenopausal women with normal skeletal muscle mass index
Clinical characteristics and bone measurements of the study population Weight, body mass index, lean mass, fat mass, femoral neck (FN) Cross sectional area (CSA), FN Z, FN cross sectional moment of inertia (CSMI), IT CSA, IT Z, IT CSMI, IT cortical thickness (CT), femoral shaft (FS) CSA, FS Z and FS CSMI were significantly higher (p < 0.05) in women with normal skeletal muscle mass index (SMI) compared to women with sarcopenia (Table 1)
Associations between body weight, lean mass, fat mass, SMI and hip structure analysis variables In the whole population (Table 2), body weight, lean mass and fat mass were positively correlated with CSA, CSMI, and CT at the FN, IT, and FS (p < 0.01) and negatively correlated with buckling ratio (BR) at the IT and FS (p < 0.01)

Summary

Introduction

The current study’s purpose is to compare hip structural analysis variables in a group of postmenopausal women with sarcopenia and another group of postmenopausal women with normal skeletal muscle mass index. The current study included 8 postmenopausal women (whose ages ranged between 65 and 84 years) with sarcopenia and 60 age-matched controls (with normal skeletal muscle mass index (SMI)). Lean mass is a major predictor of bone mineral density (BMD) and geometric indices of hip bone strength in elderly subjects [4,5,6,7,8,9]. In this population as well, fat mass is another determinant of BMD and geometric indices of hip bone strength [4,5,6,7,8,9]. Saddik et al BMC Bioinformatics 2020, 21(Suppl 2):

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Conclusion