Abstract
While sarcopenia is associated with poor overall survival and cancer-specific survival in solid cancer patients, the impact of sarcopenia on clinicopathologic features that can influence conventional papillary thyroid cancer (PTC) prognosis remains unclear. To investigate the impact of sarcopenia on aggressive clinicopathologic features in PTC patients, prospectively collected data on 305 patients who underwent surgery for PTC with preoperative staging ultrasonography and bioelectrical impedance analysis were retrospectively analyzed. Nine sarcopenia patients with preoperative sarcopenia showed more patients aged 55 or older (p = 0.022), higher male proportion (p < 0.001), lower body-mass index (p = 0.015), higher incidence of major organ or vessel invasion (p = 0.001), higher T stage (p = 0.002), higher TNM stage (p = 0.007), and more tumor recurrence (p = 0.023) compared to the non-sarcopenia patients. Unadjusted and adjusted logistic regression analyses showed that sarcopenia (odds ratio (OR) 9.936, 95% confidence interval (CI) 2.052–48.111, p = 0.004), tumor size (OR 1.048, 95% CI 1.005–1.093, p = 0.027), and tumor multiplicity (OR 3.323, 95% CI 1.048–10.534, p = 0.041) significantly increased the risk of T4 cancer. Sarcopenia patients showed significantly lower disease-free survival probability compared to non-sarcopenia patients. Therefore, preoperative sarcopenia in PTC patients should raise clinical suspicion for a more locally advanced disease and direct appropriate management and careful follow-up.
Highlights
While sarcopenia is associated with poor overall survival and cancer-specific survival in solid cancer patients, the impact of sarcopenia on clinicopathologic features that can influence conventional papillary thyroid cancer (PTC) prognosis remains unclear
A recent study showed that low thyroid stimulating hormone (TSH) levels after total thyroidectomy in PTC patients was associated with low grip strength, a parameter for assessing sarcopenia[16]
Available previous studies suggest a major role of pro-inflammatory and anti-inflammatory cytokines in sarcopenia which may influence the aggressiveness of PTC17
Summary
While sarcopenia is associated with poor overall survival and cancer-specific survival in solid cancer patients, the impact of sarcopenia on clinicopathologic features that can influence conventional papillary thyroid cancer (PTC) prognosis remains unclear. Sarcopenia is identified by low muscle strength as well as low muscle quantity and quality[2] Such changes in body composition can impact an extensive variety of disease processes, such as cardiac disease, respiratory disease, as well as some m alignancies[3–6]. Past studies have not explained whether preoperative sarcopenia can act as an aggressive clinicopathologic feature that may potentially affect the prognosis of conventional papillary thyroid cancer (PTC). This study aimed to investigate the potential implications of preoperative sarcopenia on aggressive clinicopathologic features in PTC patients
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