Abstract
Bladder cancer is the seventh most common cancer in the world. Urothelial carcinoma is the most common type of bladder cancer. Other subtypes like squamous cell carcinoma and adenocarcinoma are less common. Urothelial carcinoma has a propensity for divergent differentiation. Sarcomatoid carcinoma is one of the variants of urothelial carcinoma. It is an aggressive tumor that presents at an advanced stage and has a poorer prognosis than conventional urothelial carcinoma. Therefore, identifying this variant histology is important clinically. The sarcomatoid component in sarcomatoid carcinoma can be spindle cell (not otherwise specified), myxoid, pseudoangiosarcomatous, and undifferentiated sarcoma like. Myxoid stroma in sarcomatoid urothelial carcinoma has been described but reported very rarely. We present a case of sarcomatoid urothelial carcinoma with myxoid stroma along with a review of the diagnostic approach to myxoid spindle cell lesions of the urinary bladder.
Highlights
Bladder cancer is the seventh most common cancer in the world [1]
It is an aggressive tumor that presents at an advanced stage and has a poorer prognosis than conventional urothelial carcinoma
We present a case of sarcomatoid urothelial carcinoma with myxoid stroma along with a review of the diagnostic approach to myxoid spindle cell lesions of the urinary bladder
Summary
Bladder cancer is the seventh most common cancer in the world [1]. It is three to four times more common in men than in women and the median age of a diagnosis is 65-70 years [2]. The recent World Health Organization classification endorses the term sarcomatoid carcinoma It accounts for 0.6% of all bladder tumors [6]. The sarcomatoid component in sarcomatoid carcinoma can present with variable morphology They can be spindle cells (not otherwise specified), myxoid, pseudoangiosarcomatous, and malignant fibrous histiocytoma-like undifferentiated features. We present a case of sarcomatoid urothelial carcinoma with myxoid stroma, in a 56-year-old male patient. The tumor cells were negative for smooth muscle actin (SMA), desmin, calponin, caldesmon, anaplastic lymphoma kinase (ALK1) protein, and CD34 ruling out the differential diagnosis of leiomyosarcoma with myxoid stroma and Inflammatory myofibroblastic tumor (Figure 8). A final diagnosis of a high-grade urothelial carcinoma (grade 3) showing a spindle cell morphology (sarcomatoid carcinoma) was made. The patient was referred to a specialized oncology center for further management
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
