Abstract
Secondary cancers of the penis are extremely uncommon with less than 300 cases reported in the past 100 years. These cancers are most frequently a result of an aggressive or poorly managed primary prostate or bladder cancer and rarely a metastasis from a primary kidney tumor. Currently, there is no published literature which describes the spread of sarcomatoid renal cell carcinoma (SRCC) to the penis. In this report, we present a 55-year-old-man who presented with a large right-sided SRCC which metastasized to the base of his penis within 1 month of symptom onset. We also discuss the possible route of metastasis based on primary tumor size and location within the retroperitoneum.
Highlights
Renal cell carcinoma (RCC) is notorious for its ability to metastasize to various locations including the lung, bone, lymph nodes, and liver
An image guided biopsy of the renal mass and immunohistochemistry evidenced spindled, malignant cells (Figures 3(a) and 3(b)) with cytoplasm positive for vimentin, CD10, and AE1/AE3 (Figures 4(a), 4(b), and 4(c)) and negative for EMA, CD31, RCC, and desmin which supported a diagnosis of sarcomatoid renal cell carcinoma (SRCC)
Renal cell carcinoma (RCC), including sarcomatoid RCC, has the ability to metastasize to various locations including the lung, bone, lymph nodes, and liver
Summary
Renal cell carcinoma (RCC) is notorious for its ability to metastasize to various locations including the lung, bone, lymph nodes, and liver. Uncommon locations of metastasis include the brain, intestines, and bladder [1]. Sarcomatoid RCC (SRCC) represents a form of high grade transformation of different subtypes of RCC including clear cell, papillary, and collecting duct carcinomas. It often presents as a large mass with mean tumor size of 9-10 cm with 45–84% having evidence of systemic disease at the time of presentation [2, 3]. Secondary cancers of the penis are extremely uncommon with only around 300 cases reported in the last century. There is currently no literature that describes the metastasis of SRCC to the penis which is why this case is extremely unique and worthy of documentation
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