Abstract
The UM-X7.1 myopathic and control hamsters at 40, 120 and 280 days of age were employed for the examination of heart sarcolemmal Ca 2+-transport activities. Na +-dependent Ca 2+ uptake activities were significantly depressed in myopathic animals at 120 and 280 days of age in comparison to the control values. No difference in Na +-induced Ca 2+ release activities was found between control and experimental sarcolemmal vesicles. ATP-dependent Ca 2+ binding and Ca 2+-stimulated, Mg 2+ ATPase activities were depressed in the experimental animals at 120 and 280 days of age. Similar alterations in the sarcolemmal Na +-dependent Ca 2+ exchange and Ca 2+-pump activities were seen upon treating the control hamsters with 40 mg/kg isoproterenol for 24 hr. It is suggested that a depression in the sarcolemmal Ca 2+ transport activities may contribute to the development of intracellular Ca 2+ overload in the genetically determined cardiomyopathy in hamsters and such a defect may be due to excessive amount circulating catecholamines in these animals.
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