Sarcoidosis and Lung Cancer

Naohiro Kobayashi,Yukio Sato,Ryota Nakamura,Hiroaki Satoh,Koichi Kurishima

doi:10.14712/18059694.2016.69

Naohiro Kobayashi, Yukio Sato + Show 3 more

Open Access

https://doi.org/10.14712/18059694.2016.69

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Abstract

Although sarcoidosis as well as lung cancer are frequently encountered common diseases, their metachronous or synchronous occurrence in the same patient is very rare. The charts of lung cancer patients, diagnosed between 1980 and 2007 in our hospital, were reviewed. We found 3 cases with sarcoidosis and lung cancer. The first case had lung cancer 16 years after the diagnosis of sarcoidosis. The second case had two different metachronous lung cancers 18 and 10 years after the diagnosis of sarcoidosis. The third case detected these two diseases simultaneously. In simultaneously detected cases, it is difficult to determine whether noncaseating epithelioid cell granulomas coexisting with lung cancer represent sarcoid reaction or genuine systemic sarcoidosis. Either causality or coincidence, lung cancer, a condition that can be observed in patients with sarcoidosis, should be considered in the differential diagnosis when suspicious findings of it are discovered.

Highlights

Sarcoidosis is a systemic granulomatous disease of unknown etiology and is characterized by T cells dysfunction [13]
On chest CT scan, he had bilateral hilar and left mediastinal lymphadenopathies, in which showed abnormal uptake in gallium scintigraphy. He was diagnosed as having sarcoidosis on the basis of uveitis, lymphadenopathies, and pathological findings of noncaseating epithelioid cell granulomas, which were observed in the mediastinal lymph nodes obtained by mediastinoscopy
According to a report by Yamasawa et al [20], there have been four speculations concerning the causal relationship between sarcoidosis and lung cancer; 1) the two diseases incidentally coexist, 2) the cell-mediated immune abnormalities induced by sarcoidosis are involved in the onset of lung cancer, 3) lung cancer originates in the fibrous tissue due to sarcoidosis, and 4) the onset of sarcoidosis is caused by an immunohistological reaction such as sarcoid reactions, which respond to malig

Summary

SARCOIDOSIS AND LUNG CANCER

Summary: Background: sarcoidosis as well as lung cancer are frequently encountered common diseases, their metachronous or synchronous occurrence in the same patient is very rare. Methods: The charts of lung cancer patients, diagnosed between 1980 and 2007 in our hospital, were reviewed. Results: We found 3 cases with sarcoidosis and lung cancer. The first case had lung cancer 16 years after the diagnosis of sarcoidosis. The second case had two different metachronous lung cancers 18 and 10 years after the diagnosis of sarcoidosis. It is difficult to determine whether noncaseating epithelioid cell granulomas coexisting with lung cancer represent sarcoid reaction or genuine systemic sarcoidosis. Conclusions: Either causality or coincidence, lung cancer, a condition that can be observed in patients with sarcoidosis, should be considered in the differential diagnosis when suspicious findings of it are discovered

Introduction

Case reports

Discussion

Smoking index

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