Abstract
Abstract Sarcoid tumors were described by means of histopathological and molecular procedures in a 5-year-old donkey. Histopathological examination showed epithelial changes including hyperkeratosis, epithelial hyperplasia, koilocytosis, and rete peg formation. Neoplastic fibroblastic cells were plumb, large spindle to stellate and embedded in dense collagenous tissue. Results of Polymerase Chain Reaction and DNA sequence analysis showed that the etiological agent belonged to Bovine Papilloma Virus-II species in the delta papilloma virus genus. This case study represents the first report demonstrating the presence of Bovine Papilloma Virus-II in donkey sarcoid.
Highlights
Papillomaviridae are non-encapsulated oncogenic viruses with circular, double-stranded DNA, infecting the epithelium
Most of the studies on sarcoid tumors are focused on horses, limited numbers of studies are available in other equids [5]
Despite some studies in equine sarcoid and bovine papilloma virus exist in Turkey [6,7], to the authors’ knowledge, no report on sarcoid in donkeys is available
Summary
Papillomaviridae are non-encapsulated oncogenic viruses with circular, double-stranded DNA, infecting the epithelium. Most of the papillomaviruses are highly host specific, bovine papilloma virus (BPV) has cosmopolitan features infecting both bovine and equine species [1]. BPV-1, 2 and 13 are responsible for the occurrence of sarcoid tumors in equids [4]. Most of the studies on sarcoid tumors are focused on horses, limited numbers of studies are available in other equids [5].
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