Sarcoïdose nasosinusienne et cervicale traitée par infliximab : trois observations et revue de la littérature

Abstract

Introduction Sinonasal sarcoidosis is difficult to treat. Infliximab seems to be useful in the treatment of sarcoidosis of the upper respiratory tract. Case series We report three cases of sinonasal sarcoidosis in two women of 36 and 42-year-old and in a 64-year-old man. Resistance or dependence to corticosteroids and absence of efficacy of methotrexate therapy in one patient led to administer anti-TNFα therapy with infliximab. Outcome was favourable on sarcoid lesions but treatment was discontinued because of infectious complications and worsening of sarcoid chest involvement. Conclusion This case series suggests that infliximab might be useful for the treatment of sarcoidosis with sinonasal involvement.