Abstract
Department of Chemistry, Sogang University, Seoul 121-742, KoreaReceived August 3, 2008In continuation of our efforts to further derivatize dipeptidyl peptidase IV (DPP-IV) inhibitors, a series of β-aminoacyl-containing 5-, 6- and 7- membered cyclic hydrazide derivatives was synthesized. All thecompounds were evaluated for their ability to inhibit DPP-IV, and an optimum structural unit on basic skeletonis identified to show good in vitro activity.Key Words : Dipeptidyl peptidase IV, Diabetes, Cyclic hydrazideIntroductionA non-insulin dependent diabetes mellitus (NIDDM) ischaracterized by chronic hyperglycemia, and belongs to agroup of metabolic disorders with multiple etiologies. It isvery common and may result from insulin resistance, inade-quate secretion of insulin, hepatic glucose overproduction,or glucose intolerance.
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