Abstract

Introduction: Saprochete capitata is unusual etiologic agent in immunocompromised patients, particularly in those with hematologic malignancy and severe neutropenia. Most often, infections of the oral cavity are manifested clinically as oral candidiasis. Invasive forms are rarely described. Observation: a 63-year-old man consulted for pseudomembranous lesions associated with ulcero perforating lesion of the tongue and palatal region ulcerations. All evolving in a context of profound physical deterioration and severe neutropenia. Mycological examination showed Saprochaete capitata. The evolution was favorable with oral voriconazole. Comment: Saprochaete capitata invasive fungal infections have become an important cause of morbidity and mortality, particularly in hematology-oncology patients. Invasive or non-invasive, oropharyngeal involvement with this pathogen should not be underestimated in the neutropenic patient. They are the main starting point for fongemia of this pathogen, which is often fatal. Conclusion: Saprochete capitata is now recognized emerging etiologic agent in patients with hematological malignancy and severe neutropenia. Early detection and diagnosis of these fungal infections could lead to reduced morbidity and mortality, particularly in locally invasive infection.

Highlights

  • Saprochaete capitata (S. capitata), formerly known as Geotrichum capitatum, is an ascomycete fungus which has subject of several taxonomic revisions in recent decades [1]

  • We report a rare case of S. capitata invasive oropharyngeal infection in a neutropenic patient, through which will describe the clinical, biological and therapeutic aspect of this infection and comparison with published data

  • Invasive or non-invasive, oropharyngeal involvement with this pathogen should not be underestimated in the neutropenic patient, Özdemir ZC et al reported three cases of fatal fungemia at this yeast in patients of acute lymphoblastic leukemia whose starting point was an oral fungal infection [13]

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Summary

Introduction

Saprochaete capitata (S. capitata), formerly known as Geotrichum capitatum, is an ascomycete fungus which has subject of several taxonomic revisions in recent decades [1]. S. capitata Infections are very common and occur almost exclusively in immunocompromised patients, those with hematologic malignancy and severe neutropenia [3,4]. We report a rare case of S. capitata invasive oropharyngeal infection in a neutropenic patient, through which will describe the clinical, biological and therapeutic aspect of this infection and comparison with published data.

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