Abstract
Background and purpose: As an herbal medicine, adzuki bean has been practiced since the Tang Dynasty of China to maintain health and control weight; this practice is still very popular in China nowadays. However, it is still lack of sufficient scientific basis to explain scientific principle of this popular civil practice in weight control using adzuki bean. The purpose of this study was to verify and explain the anti-obesity effects of adzuki bean through in vitro enzymatic assays, in vitro lipolysis and in vivo study of obese mice model.Methods: Inhibitory effects of flavonoids and saponins from adzuki bean (Vigna angularis) on pancreatic lipase, α-glucosidase activities, and noradrenaline-induced lipolysis were assessed. High-fat diet-induced obesity model was created to study anti-obesity effects of adzuki bean. Both serum and liver lipid parameters were determined after 8 weeks intervention.Results: Adzuki bean extracts enhanced lipolysis. Compared to the final body weight of high-fat diet group, oral administration of adzuki bean significantly (p < 0.05) reduced the final body weight of mice and adipose tissue accumulation. The adzuki bean intervention also significantly reduced the levels of serum triglyceride, total cholesterol, low density lipoprotein-cholesterol, and liver lipid.Conclusion: Adzuki bean demonstrated the anti-obesity effects on mice, such effects may mediated through the inhibitory effects of flavonoids and saponins from adzuki bean on α-glucosidase and pancreatic lipase activities, and lipolysis enhancement effect of active components from adzuki bean.
Highlights
Overweight and obesity are defined by World Health Organization (WHO) as abnormal or excessive fat accumulation that presents a risk to health
Eluent of 40% ethanol from polyamide column was obtained, and the fraction was rich in flavonoids
Precipitation with methanol– acetone was applied to further separate flavonoids and saponins from adzuki bean
Summary
Overweight and obesity are defined by World Health Organization (WHO) as abnormal or excessive fat accumulation that presents a risk to health. Overweight and obesity lead to many serious diseases, such as high blood pressure, diabetes, Anti-obesity Effect of Adzuki Bean strokes, cancers (Kushner, 2002; Festi et al, 2004; Nammi et al, 2004; WHO, 2010). Consumption of bioactive compounds from diet or intake of dietary supplementation is one of possible ways to control obesity and to prevent or reduce the risks of developing various obesity-related diseases. Adzuki bean has been practiced since the Tang Dynasty of China to maintain health and control weight; this practice is still very popular in China nowadays. It is still lack of sufficient scientific basis to explain scientific principle of this popular civil practice in weight control using adzuki bean. The purpose of this study was to verify and explain the anti-obesity effects of adzuki bean through in vitro enzymatic assays, in vitro lipolysis and in vivo study of obese mice model
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