SANTYL® Collagenase as an effective debriding agent for burn wounds

Abstract

Purpose: To demonstrate the effectiveness of using SANTYL® Collagenase in conjunction with mechanical debridement as the primary source of treatment for burn patients. This case report was on 61-year-old male with uncontrolled Type II Diabetes Mellitus, diabetic peripheral neuropathy, hypertension, and other comorbidities who presented with 1st degree burns on dorsum of 1st interdigital space of right foot. Methods: Mechanical debridement was performed initially at every encounter. Sterile Saline was then applied to clean the wound. Application of enzymatic debridement agent SANTYL® Collagenase (2mm thick) over the wound daily to obtain good clean granular base. Apply clean, dry and sterile dressingwithAquaphor® spray daily for moisture management. Patient was put into partial immobilization device to decrease forces to area of concern. Results: Baseline: The wound measured 0.8 cm×2.5 cm×0.1 cm. Wound had an eschar present, no drainage, erythematous base, and peeling of wound margins. Day 8: The wound measured 0.4 cm×1.25 cm×0.05 cm after sharp and enzymatic debridement (Santyl® Collagenase). There was no drainage present, decrease in erythematous base, no eschar present, and clear margins Day 15: The wound had fully healed without any presence of eschar or debris. Conclusions: The overall results show that using Santyl® Collagenase in conjunction with mechanical debridement was effective in treating burn wounds. Santyl® Collagenase is quick acting, removes devitalized tissue, results in full clearance, and causes less discomfort to the patient. The combination of this therapy allowed complete closure of the burnwound in under 28 days time. Further research should be conducted to support the efficacy of Santyl® Collagenase on different types of wounds.