Abstract

BackgroundIn-person mass gathering events (MGE) are returning after a period of restrictions, yet few prospective scientific evaluations of their safety are available.MethodsProspective observational study, including both attendees of the French Intensive Care Society (FICS) annual meeting held in Paris between June the 9th and June the 11th, 2021 and matched controls (healthcare professionals who stayed in the ICU during the conference). SARS-CoV-2 lateral flow test was performed on day 7. Follow-up occurred until day 21.ResultsOut of the 1824 healthcare professionals attending the congress (all of which fulfilled legal requirements: 7 days or more following a second dose of vaccine or a negative PCR test performed within less than 72 h), 520 (28.5%) agreed to participate. Follow-up data were received for 216 (41.5%) out of the 520 included attendees, and for 191 matched controls. No positive SARS-CoV-2 lateral flow test was reported in the attendees or in the matched controls. The probability of SARS-CoV-2 infection during the MGE was less than 1.7% in the attendees (95% confidence interval [0;1.7%]), less than 2% in the controls (95%CI [0;2%]) and the difference in probabilities of infection was less than 1.9% (95% CI [0;1.9%]).ConclusionDuring a low incidence period, in this population of congress attendees screened for SARS-CoV-2 by a lateral flow test at day 7, no positive cases could be documented, no concomitant infection occurred in the matched controls; suggesting no extra risk of infection during the MGE.Trial Registration: ClinicalTrial.gov, #NCT04918160.

Highlights

  • Non-pharmacological interventions aimed at preventing SARS-CoV-2 transmission include contact tracing and quarantine of cases, up to lockdowns when rates of infection are higher as well as physical distancing; which includes limiting the occurrence of mass gathering events (MGE), [1]

  • In a pivotal study conducted in Spain, out of 465 spectators of a live music event, 13 (3%) subjects were found to be positive for SARS-CoV-2 antigen testing [4]

  • In France, Delaugerre et al in a randomized controlled trial with almost 4000 attendees, found than participation in a large, indoor, live gathering without physical distancing was not associated with increased SARS-CoV-2 transmission risk, provided a comprehensive preventive intervention was implemented [6]

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Summary

Introduction

Non-pharmacological interventions aimed at preventing SARS-CoV-2 transmission include contact tracing and quarantine of cases, up to lockdowns when rates of infection are higher as well as physical distancing; which includes limiting the occurrence of mass gathering events (MGE), [1]. Despite improved capacities of detecting SARS-CoV-2 infections, few prospective assessments of the sanitary safety of mass gathering events (MGE) have been performed. In a pivotal study conducted in Spain, out of 465 spectators of a live music event, 13 (3%) subjects were found to be positive for SARS-CoV-2 antigen testing [4]. The same team found in a subsequent study, found that out of 5000 subjects willing to spectate a live music event, 6 were tested positive for SARS-CoV-2 [5]. These observations occurred prior to mass vaccination of the population. In-person mass gathering events (MGE) are returning after a period of restrictions, yet few prospective scientific evaluations of their safety are available

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