Abstract
A new, rare trinor-dolabellane diterpenoid, sangiangol A (1), and one new dolabellane diterpenoid, sangiangol B (2), together with known cembranes and dolabellanes (3–8), were isolated from the ethyl acetate layer of an extract of an Indonesian marine soft coral, Anthelia sp. Compounds 1–8 exhibited moderate cytotoxicity against an NBT-T2 cell line (0.5–10 µg/mL). The structures of the new compounds were determined by analyzing their spectra and a molecular modelling study. A possible biosynthetic pathway for sangiangols A (1) and B (2) is presented. Cytotoxicity requires two epoxide rings or a chlorine atom, as in 4 (stolonidiol) and 5 (clavinflol B).
Highlights
Soft corals produce numerous, structurally diverse, biologically active terpenoids [1]
Cembrane and briarane skeletons comprise a majority of the known diterpenoids in soft corals globally [2,3]
In our continuing study of metabolites of Indonesian Anthelia [4,6], we isolated known diterpenoids 3–8 and new dolabellanes, named sangiangols A (1) and B (2), the structures of which are the subject of this article
Summary
Structurally diverse, biologically active terpenoids [1]. From 1970–2017, eight diterpenoid skeletons (briarane, cladiellane, seco-cladiellane, cembrane, nor-cembrane, dolabellane, flexibilane, and xenicane) were discovered in 11 genera of Indonesian alcyonaceans [2]. Soft corals of the genus Anthelia, family Xeniidae, have been shown to contain one type of sesquiterpenoid [4], three types of diterpenoids (xenicane [5], dolabellane [6], a C24 -acetoacetylated diterpenoid [7,8]), and one type of steroid [9] with cytotoxic activity against various cell lines [4,5,6,7,8,9]. In our continuing study of metabolites of Indonesian Anthelia [4,6], we isolated known diterpenoids 3–8 and new dolabellanes, named sangiangols A (1) and B (2), the structures of which are the subject of this article
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