Abstract
Speckle degrades the quality of optical coherence tomography (OCT) images and impedes their visual interpretation. Current hardware methods for speckle suppression necessitate difficult hardware modifications. As a result, algorithmic approaches for speckle suppression generally lack validation or training with physically meaningful ground truth. Here, we demonstrate angular compounding through tilting of the sample with a motorized rotation stage. Tomograms acquired at different tilt angles are related to each other through a physics-informed affine map, which can be retrieved directly from the measurement data. Using a mechanical sample tilting stage obviates the need to alter the OCT hardware and enables effective angular compounding with existing OCT instruments.
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