Abstract
Errors made during the sample preparative process contribute significantly to the total analytical error of immunoassays. Reduction in the magnitude of these errors have been made by improvements in the manualfluid handling systems and mechanization of the individual steps in the process. The mechanization has been stimulated by developments in both computing hardware and software. A laboratory's workflow and workload will indicate the degree of mechanization required.
Highlights
Errors made during the sample preparative process contribute significantly to the total analytical error of immunoassays
Reduction in the magnitude of these errors have been made by improvements in the manualfluid handling systems and mechanization of the individual steps in the process
This paper concentrates upon sample preparation and processing
Summary
Reduction in the magnitude of these errors have been made by improvements in the manualfluid handling systems and mechanization of the individual steps in the process. This has changed with a large number of manufacturers offering immunoassay systems, each with varying degrees of mechanization. The method used for the mechanization of sample processing is dictated to a large degree by two factors: the complexity of the task and the volume of work to be performed. Variable mechanization, where the procedure steps are programmed at the beginning of each batch, is cost effective for medium workload with low to high complexity of sample preparation. Fixed program analysers and dedicated robots are effective when handling high sample volumes with a range of processes with varying complexities
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