Abstract
This chapter addresses the adulteration of urine samples and its effect on drugs-of-abuse testing using on-site testing devices. The technical aspects of on-site testing methodologies are described in detail elsewhere in this book and will not be described in this chapter. Current literature regarding adulteration of urine samples and its impact on on-site tests is nearly non-existent. As a result, this chapter describes some adulterants and focuses on their effects on the analyte of interest along with some relevant discussion of effects of the adulterants on laboratory immunoassay and GC-MS testing. Those adulterants that directly effect the drug (or metabolite) will impact results regardless of which methodology is used, including on-site tests. In addition, tests available for the detection of adulterants that can be used at the collection-site are also described in this chapter.
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