Abstract
In this perspective, I summarize the current evidence that salvinorin A could be used for stroke rescue. A recent study to demonstrate the effectiveness of intranasal salvinorin A to improve long term neurological outcome in a monkey ischemic stroke model is very promising. Current accumulated evidence indicates that salvinorin A can improve stroke outcome through various mechanisms. While salvinorin A has side effects of diuresis, hypothermia, reduced brain metabolism, and psychotropic effects, these could potentially all contribute to protective effects in the setting of stroke.
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