Abstract
The anxiolytic and antidepressant like effects of Salvia officinalis extract (50, 100 and 200 mg/kg) were evaluated using marble burying, forced swimming and open-field tests in intact and hippocampal lesioned rats. Additionally, S. officinalis was evaluated on rat's memory using conditioned learning test. and we screened the methanolic extract for anti-oxidant activity, phytochemical and high performance liquid chromatography analyses. The administration of sage extract showed a significant reduction of immobility time in lesioned and intact animals during the forced swim test and anxiolytic effect in marble burying test. In the case of conditioned learning paradigm, memory enhancement was observed in sage treated group which indicates a cognition improvement. These activities seem to be related to the anti-oxidant capacity and the phytochemicals (phenolic, flavonoid, and tannin) detected into the extract of S. officinalis. The findings show that the methanolic extract of sage possess antidepressant-like effect, anxiolytic activity and also may contain bioactive compounds that stimulate learning in rat.
Highlights
Several synthetic and chemical drugs have been introduced to treat patients with various neurological disorders, but their therapeutic effects have modest efficacy and most of them are associated with several adverse effects indicating need of better-tolerated and more efficacious treatments (Kim and Oh, 2012)
The effects of methanolic extract of S. officinalis in the DPPH, iron (II) chelating activity and β-carotene/ linoleic acid bleaching assay are shown in Figure 2, which was comparable to that of the standard antioxidant butylated hydroxytoluene, quercetin, vitamin C and E
As the better anti-oxidant activity was reflected by the lower IC50 values, the results showed that methanolic extract exhibited the highest anti-oxidant activity
Summary
Several synthetic and chemical drugs have been introduced to treat patients with various neurological disorders, but their therapeutic effects have modest efficacy and most of them are associated with several adverse effects indicating need of better-tolerated and more efficacious treatments (Kim and Oh, 2012). Medicinal plants have been a major source of natural active compounds that can provide important options for developing drugs for the treatment of different mood and neurological disorders. (Lamiaceae, common sage) is an aromatic and medicinal plant native to the Mediterranean region, extensively used since ancient times in folk medicine (Penso, 1983). It is known in Arabic as “almufassiha” because it helps who take it to talk fluently, and in Morocco, it is called Salmiya, commonly used in the food especially to flavor the tea and for the treatment of various diseases. Experimental evidence supports several biological activities for different types of S. officinalis extracts, including anti-oxidant (Lu and Yeap Foo, 2001), antihyperglycaemic (Alarcon-Aguilar et al, 2002; Behradmanesh et al, 2013), gastroprotective
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