Salvia miltiorrhiza and ligustrazine injection combined with cilostazol for patients with lacunar infarction

Abstract

Objective To explore the efficacy of salvia miltiorrhiza and ligustrazine injection combined with cilostazol in the treatment of patients with lacunar infarction. Methods 50 patients with lacunar infarction treated at our hospital from January, 2016 to January, 2018 were selected and divided into a control group (n=25) and an observation group (n=25) according to different treatments. The control group was treated with cilostazol, and the observation group with salvia miltiorrhiza and ligustrazine injection and cilostazol. The treatment efficacy as well as the Hasegawa Intelligent Scale (HDS) score, cerebrovascular function (blood inflow time and cerebral blood flow), hemorheology indicators (plasma viscosity, fibrinogen, whole blood viscosity shear rate) , and the levels of levels adiponectin (APN), endothelin (ET)-1, thromboxane B2 (TXB2) before and after the treatment were compared between the two groups. Results The total effective rate of the observation group was higher than that of the control group (P<0.05). After the treatment, the HDS score, cerebral blood flow, and APN level were higher, the blood inflow time was shorter, and the plasma viscosity, fibrinogen and whole blood viscosity shear rate as well as the levels of ET-1 and TXB2 were lower in the observation group than in the control group (all P<0.05). Conclusion Salvia miltiorrhiza and ligustrazine injection combined with cilostazole in the treatment of patients with lacunar cerebral infarction can resist atherosclerosis, improve hemorheology and cerebrovascular function, enhance cognitive function, and protect endothelial function, and is remarkably effective. Key words: Salvia miltiorrhiza and ligustrazine injection; Cilostazole; Lacunar cerebral infarction