Salvage therapy of intensively pretreated patients with epithelial ovarian cancer and other Müllerian tract carcinomas with treosulfan and gemcitabine

Abstract

Objectives: The prognosis of intensively pretreated patients (pts) with epithelial ovarian carcinoma (EOC) and related malignancies having failed multiple chemotherapy (CTx) regimens is poor, irrespectively of the individual platinum-resistance status. In preceding studies, the combination of treosulfan and prolonged low-dose gemcitabine (GeT) has shown promising activity in pretreated, mainly platinum-resistant EOC. This retrospective study has been set up in order yield more detailed information about the clinical value of GeT administered under routine conditions.