Abstract
Prostate-specific membrane antigen (PSMA)-based positron emission tomography (PET) imaging allows early detection of metastases in patients with biochemical recurrence. Salvage lymphadenectomy became awidely used method of metastasis-directed treatment. Retrospective analyses show that alow prostate-specific antigen (PSA) value and presence of no more than two affected lymph nodes within the pelvis are factors associated with agood outcome. In all, 40-80% of patients achieve acomplete biochemical response with amean time without biochemical recurrence of 8months and aprolonged treatment-free interval. About 10% of patients with acomplete biochemical response will live without recurrence after 10years. The utilization of PSMA-radioguided surgery increases the likelihood of intraoperative detection of suspicious affected lymph nodes. Complications can mostly be avoided by prudent patient selection and surgical expertise.
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