Salt Effect on the Cloud Point Phenomenon of Amphiphilic Drug-Hydroxypropylmethyl Cellulose System

Mohd Sajid Ali,Dileep Kumar,Hamad A Al-Lohedan

doi:10.1155/2014/293972

Mohd Sajid Ali, Dileep Kumar + Show 1 more

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https://doi.org/10.1155/2014/293972

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Abstract

Effect of two amphiphilic drugs (tricyclic antidepressant, nortriptyline hydrochloride (NORT), and nonsteroidal anti-inflammatory drug, sodium salt of ibuprofen (IBF)) on the cloud point of biopolymer hydroxypropylmethyl cellulose (HPMC) was studied. Effect of NaCl was also seen on the CP of HPMC-drug system. CP of HPMC increases uniformly on increasing the (drug). Both drugs, though one being anionic (IBF) and other cationic (NORT), affect the CP in almost the same manner but with different extent implying the role of hydrophobicity in the interaction between drug and polymer. Salt affects the CP of the drug in a dramatic way as low concentration of salt was only able to increase the value of the CP, though not affecting the pattern. However, in presence of high concentration of salts, minimum was observed on CP versus (drug) plots. Various thermodynamic parameters were evaluated and discussed on the basis of the observed results.

Highlights

Owing to their nontoxic nature, derivatives of a number of biopolymers play important roles in food, pharmaceutical, and cosmetics industries where careful addition can be used to regulate the rheology of the system [1]
In this study effect of two amphiphilic drugs, nortriptyline hydrochloride (NORT) and sodium salt of ibuprofen (IBF), on the phase separation of cellulose ether hydroxypropylmethyl cellulose (HPMC) was seen in pure aqueous medium and in presence of NaCl
Experimental Section hydroxypropylmethyl cellulose, HPMC, nortriptyline hydrochloride, NORT (99.0%, Sigma, USA), sodium salt of ibuprofen, IBF (>99%, Sigma, USA), were used as received

Summary

Introduction

Owing to their nontoxic nature, derivatives of a number of biopolymers (cellulose, starch, etc.) play important roles in food, pharmaceutical, and cosmetics industries where careful addition can be used to regulate the rheology of the system [1]. In this study effect of two amphiphilic drugs, nortriptyline hydrochloride (NORT) and sodium salt of ibuprofen (IBF), on the phase separation of cellulose ether HPMC was seen in pure aqueous medium and in presence of NaCl. 2. Effect of Amphiphilic Drugs on Cloud Point of HPMC.

Results

Conclusion