SALMONELLABASE - An online database of druggable targets of Salmonella species.

Ophilia Benedict Pushpa,Muthaiyan Xavier Suresh

doi:10.6026/97320630008734

Ophilia Benedict Pushpa, Muthaiyan Xavier Suresh

Open Access

https://doi.org/10.6026/97320630008734

Copy DOI

Abstract

Salmonellosis is one of the most common and widely distributed food borne diseases caused by Salmonella serovars. The emergence of multi drug resistant strains has become a threatening public health problem and targeting unique effectors of this pathogen can be considered as a powerful strategy for drug design. SalmonellaBase is an online web portal serving as an integrated source of information about Salmonella serovars with the data required for the structural and functional studies and the analysis of druggable targets in Salmonella. We have identified several target proteins, which helps in the pathogenicity of the organism and predicted their structures. The database will have the information on completely sequenced genomes of Salmonella species with the complete set of protein sequences of the respective strains, determined structures, predicted protein structures and biochemical pathways of the respective strains. In addition, we have provided information about name and source of the protein, Uniprot and Protein Data Bank codes and literature information. Furthermore, SalmonellaBase is linked to related databases and other resources. We have set up a web interface with different search and display options so that users have the ability to get the data in several ways. SalmonellaBase is a freely available database.Availabilityhttp://www.salmonellabase.com/

Highlights

Salmonellosis is one of the most common and widely distributed food borne diseases caused by Salmonella serovars
Since typhoid is becoming difficult to treat with conventional drugs, information about the whole genome sequence and genes of S. enterica serovar Typhi will help to reveal more specific targets for drugs aimed at disease treatment and vaccines for prevention
Over the past few decades the nucleotide and protein sequence data have been accumulated and available in number of public databases [7, 8]. Such databases are broad in scope and there is a gap between the public databases and the small curated databases focusing on a particular organism or a type of data

Summary

Introduction

Salmonellosis is one of the most common and widely distributed food borne diseases caused by Salmonella serovars. Salmonella enterica serovar Typhi is a human-specific pathogen causing enteric typhoid fever, a severe infection of the reticuloendothelial system. The early administration of antibiotic treatment has proven to be highly effective in eliminating infections, but indiscriminate use of antibiotics has led to the emergence of multidrug-resistant strains of S. enterica serovar Typhi [1,2,3,4]. Since typhoid is becoming difficult to treat with conventional drugs, information about the whole genome sequence and genes of S. enterica serovar Typhi will help to reveal more specific targets for drugs aimed at disease treatment and vaccines for prevention. Over the past few decades the nucleotide and protein sequence data have been accumulated and available in number of public databases [7, 8]. We have developed SalmonellaBase, an online database with the data required for the structural and functional studies of Salmonella serovars’ druggable targets

Methods

Conclusion