Abstract
Salmonella Host?Pathogen Interactions: A Special Topic
Highlights
One of the first contacts Salmonellae make in the intestine, the colon, is with other bacteria or normal flora. Ahmer and Gunn (2011) describe the factors involved in overcoming “colonization resistance,” mediated by normal flora and the gut innate immunity
Hallstrom and McCormick (2011) describe how Salmonella overcomes these hurdles and exploits the host defenses for their own purposes. They walk the reader through intestinal entry, the mucus layer, the intestinal epithelium [with focused discussion of M-cells as well as a paracellular pathway of entry], and into phagocytes where they are trafficked to the mesenteric lymph nodes
The review of a manuscript by Akopyan et al (2011) by Perrett and Zhou (2011) discusses data showing that this process may occur by two steps – secretion to the bacterial surface followed by Type III secretion systems transport
Summary
One of the first contacts Salmonellae make in the intestine, the colon, is with other bacteria or normal flora. Ahmer and Gunn (2011) describe the factors involved in overcoming “colonization resistance,” mediated by normal flora and the gut innate immunity. One of the first contacts Salmonellae make in the intestine, the colon, is with other bacteria or normal flora. Ahmer and Gunn (2011) describe the factors involved in overcoming “colonization resistance,” mediated by normal flora and the gut innate immunity.
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