Salmonella enterica.

Abstract

Salmonella enterica is a zoonotic pathogen of substantial concern to global human and animal health. It is a leading cause of morbidity and mortality in people worldwide. S. enterica can successfully colonize animals, humans, and plants, and is also found in the environment. Some serovars have a broad host range (S. Typhimurium and S. Enteriditis), others are host-adapted (S. Typhi and S. Paratyphi A and C). Following ingestion, S. enterica invades the intestinal epithelium in the ileum and colon, either to cause a neutrophilic gastroenteritis or disseminate to systemic sites and cause sepsis. It thrives in the intracellular niche, allowing intrinsic antimicrobial resistance and chronic colonization in rare cases. Here, we describe the phylogeny, disease features, and key molecular mechanisms underlying the pathogenesis of salmonellosis. Salmonella entericaKnodler et al.Trends in MicrobiologyNovember 18, 2019In BriefDOI of original article: https://doi.org/10.1016/j.tim.2019.05.002 Full-Text PDF