Abstract
BackgroundSystemic sclerosis (SSc) is an autoimmune disease characterized by progressive fibrosis of the skin and the internal organs. In a previous work we suggested a correlation between levels of salivary psoriasin (S100A7) and pulmonary involvement in SSc patients. The goals of this study are to determine the distribution characteristics of psoriasin in whole saliva (WS) of SSc and healthy donor populations and define its predictive value on diffusion capacity of carbon monoxide (DLCO), along with others clinical parameters.MethodsSalivary level of psoriasin was determined by ELISA kit in 134 SSc patients, 63 Raynaud syndrome patients, 40 patients affected by other connective diseases (non-case) and 74 healthy control subjects.ResultsA significant increase of salivary psoriasin was observed in SSc patients when compared with other healthy and pathological controls. Moreover, we confirmed the efficacy of salivary psoriasin to correlate with DLCO in a large cohort of SSc patients.ConclusionsOverall our results suggest a rapid, non invasive and low costing method which can help clinicians in the evaluation of SSc pulmonary involvement.
Highlights
Systemic sclerosis (SSc) is an autoimmune disease characterized by progressive fibrosis of the skin and the internal organs
Starting from preliminary results, in this work we extended the evaluation of the presence of salivary psoriasin and its correlation with clinical parameters in a large cohort of SSc patients
Using a proteomic approach, we have shown several S100 proteins are altered in SSc whole saliva (WS) including S100A7 [8, 12]
Summary
Systemic sclerosis (SSc) is an autoimmune disease characterized by progressive fibrosis of the skin and the internal organs. In a previous work we suggested a correlation between levels of salivary psoriasin (S100A7) and pulmonary involvement in SSc patients. In a previous study using a proteomic approach, we have shown an association of salivary psoriasin with SSc clinical manifestations suggesting 12 kDa psoriasin as a potential predictor of pulmonary involvement [8]. Starting from preliminary results, in this work we extended the evaluation of the presence of salivary psoriasin and its correlation with clinical parameters in a large cohort of SSc patients. The aims of this study were: (1) to determine salivary psoriasin concentrations by a specific ELISA kit; (2) to define the distribution characteristics of salivary psoriasin levels in SSc patient and healthy subject populations by SPSS statistic analysis; (3) to confirm the correlation of the presence of salivary psoriasin with pulmonary involvement in the SSc population
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