Abstract
The aim of this study was to investigate the neutrophils level in saliva as an adequate alternative to other methods for evaluating the neutrophil engraftment after autologous stem cell transplantation (ASCT) in hemato-oncology. A total of 35 patients treated for non-Hodgkin's lymphoma or multiple myeloma were stomatologically examined before planned high-dose chemotherapy with ASCT. After removal of potential foci of odontogenic infection all the patients underwent transplantation and during the treatment they were monitored for the level of neutrophils in saliva as a possible early indicator of the neutrophil engraftment. Neutrophil levels in saliva were compared to the neutrophil level in blood and to the degree of oral mucositis (the nurses study). An increase of salivary neutrophils in the mouth rinse of > 25 x 10/\6/l was identified as an early sign of successful neutrophil engraftment that occurred 1 to 2 days before the rise of neutrophils in peripheral blood (> 0.5- x 10/\9/l). Follow-up of neutrophil levels in saliva might be an adequate alternative to other methods for evaluating the neutrophil engraftment after ASCT in hemato-oncology.
Highlights
High dose chemotherapy with the support of autologous peripheral stem cell grafts (ASCT) has been considered as standard treatment for a number of hematological malignancies
The sample included a total of 35 patients treated at the Department of Hemato-Oncology of the University
All the patients were treated on the basis of established treatment protocols for non-Hodgkin’s lymphomas and multiple myeloma
Summary
High dose chemotherapy with the support of autologous peripheral stem cell grafts (ASCT) has been considered as standard treatment for a number of hematological malignancies. Aggressive chemotherapy, apart from having systemic side effects, is followed by severe oral mucositis with significant impact on the psychological well–being of the patient. To avoid this development, preventive dental intervention is necessary and this should take place prior to the start of the oncological treatment: all potential infectious foci must be healed, devitalized teeth have to be removed and patients must be instructed in the principles of oral hygiene. The sample included a total of 35 patients treated at the Department of Hemato-Oncology of the University. All the patients were treated on the basis of established treatment protocols for non-Hodgkin’s lymphomas and multiple myeloma. Before inclusion in the study, they signed a written informed consent to the treatment protocol approved earlier by the local institutional Ethical Committee
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