Abstract
Background Recurrent aphthous stomatitis is a common oral mucosa disease, with no specific etiology. Atopy has been implicated in the development of this disease. In this study, the salivary levels of immunoglobulin E (IgE) and eosinophil cationic protein (ECP) were measured as allergy-related biomarkers in patients with aphthous stomatitis. Material and Methods In this case-control study, non-stimulated saliva was collected from 85 participants and IgE and ECP were measured. Data were analyzed in SPSS 20 through the Mann-Whitney test, and p<0.05 was considered significant. Results The salivary levels of IgE and ECP were 1.11±0.65 Iu/ml and 26.93±6.95 ng/ml in the case group and 0.73±0/39 Iu/ml and 21.97±6.72 ng/ml in the control group. There was a significant difference between the two groups in terms of salivary levels of IgE and ECP (p=0.001). Conclusions The results showed that patients with oral aphthous had higher levels of salivary IgE and ECP than controls. Therefore, measurement of these biomarkers may be useful in the initial evaluation of patients with aphthous stomatitis. Key words:Recurrent aphthous stomatitis, saliva, immunoglobulin E, eosinophil cationic protein.
Highlights
Recurrent aphthous stomatitis (RAS) is a common oral mucosa disease [1,2,3,4,5] characterized by recurrent ulcers limited to the oral cavity without any symptoms of other diseases [4]
In this study, 41 patients with recurrent aphthous stomatitis (25 males and 16 females) with an average age of 29 years were selected as the case group and 44 healthy subjects (21 males and 23 females) with an average age of 27 years were selected as the control group
Given the abnormal distribution of immunoglobulin E (IgE) and eosinophil cationic protein (ECP) levels, Mann-Whitney test was used, which revealed a significant relationship between recurrent aphthous stomatitis and increased salivary levels of IgE and ECP (p
Summary
Recurrent aphthous stomatitis (RAS) is a common oral mucosa disease [1,2,3,4,5] characterized by recurrent ulcers limited to the oral cavity without any symptoms of other diseases [4]. Given the possible relationship of allergy and aphthous stomatitis, evaluation of allergy-related biomarkers, including eosinophil cationic protein (ECP) and immunoglobulin E (IgE), can be helpful in patients with aphthous stomatitis. No study has been conducted on the salivary levels of ECP in patients with aphthous stomatitis. The salivary levels of immunoglobulin E (IgE) and eosinophil cationic protein (ECP) were measured as allergy-related biomarkers in patients with aphthous stomatitis. Conclusions: The results showed that patients with oral aphthous had higher levels of salivary IgE and ECP than controls. Measurement of these biomarkers may be useful in the initial evaluation of patients with aphthous stomatitis
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