Salivary HSP70 and Progesterone are Upregulated in Preeclamptic Antenatal Mothers

Abstract

Introduction and Aim: Most of the pregnancies are complicated with complexities due to the environment, psychological, physiological circumstances. It is crucial to diagnose the pregnant women for complications during the earlier stages of pregnancy. Most importantly, the ability to monitor health status, disease onset, and the progression and treatment outcome through non-invasive means is a highly desirable goal in healthcare management. In that, the saliva represents a suitable, potential, and alternative biological filtrate/diagnostic fluid/medium for exploring the surveillance of health and disease. Also, it offers further opportunities as a pool containing a vast repertoire of specific, biologically-active peptides and proteins. Since hypertension represents the major risk contributing to diverse pregnancy complications; the present study is aimed to quantify the level of HSP70 and Progesterone in the saliva of normotensive and preeclamptic antenatal mothers.
 
 Materials and Methods: A saliva sample was collected from normotensive and preeclamptic antenatal mothers (n=10 each group) by passive drool method. Progesterone and HSP70 were quantified using ELISA kits.
 
 Results: The present study shows an increase in the expression of HSP70 and Progesterone in the salivary sample of preeclamptic pregnant women.
 
 Conclusion: Results with a higher value of HSP70 protein expression suggests that salivary HSP70 may serve as a novel and valuable marker in diagnosing pregnancy complicated with hypertensive disorders and salivary progesterone may be used as an indicator for imminent delivery in pregnant women.