Abstract
Objective: The objective of the present study was to find a non-invasive method of sample collection that can be used to diagnose and monitor diabetes mellitus (DM).
 Methods: In this study, saliva as a diagnostic fluid was collected noninvasively from subjects with modest training and this offers a cost-effective method for screening diabetes. To evaluate the association of blood glucose level with salivary glucose in Type-II diabetic (Type-II D) patients, a case– control study was conducted on 200 test and 200 healthy control people in selected study village in Kanchipuram (District). The glucose level was measured in saliva and blood plasma by glucose oxidase and peroxidase method.
 Results: A highly significant positive correlation between fasting salivary glucose (69.377±14.329 mg/dl) and plasma glucose (249.935±64.65 mg/dl) in diabetic patients and in control group, plasma glucose level 117.545±10.595 and saliva glucose level 49.271±13.795 mg/dl was observed.
 Conclusion: From this study, it can be concluded that fasting salivary glucose level can be used as a non-invasive diagnostic, as well as monitoring tool to assess the glycemic status of Type-II DM patients.
Highlights
IntroductionDiabetes mellitus (DM) is a heterogeneous (clinically and genetically) metabolic disease characterized by hyperglycemia and dysregulation of carbohydrate, protein, and lipid metabolism [1]
Diabetes mellitus (DM) is a heterogeneous metabolic disease characterized by hyperglycemia and dysregulation of carbohydrate, protein, and lipid metabolism [1]
Elevated plasma glucose concentration was observed in diabetic patient than the control people at p
Summary
Diabetes mellitus (DM) is a heterogeneous (clinically and genetically) metabolic disease characterized by hyperglycemia and dysregulation of carbohydrate, protein, and lipid metabolism [1]. DM in India is gaining the status of a potential epidemic disease with more than 62 million people diagnosed with DM [3,4]. Blood has been the most commonly used diagnostic fluid for the analysis of its various constituents. This study is focused on the fact that saliva being the principle and defensive fluid in the mouth with informative components can serve as diagnostic tool for human diseases. Collection of saliva is cost effective and non-invasive when compared to blood. The present study is proposed to measure the correlation between salivary and blood glucose levels in diabetic and non-diabetic subjects
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