Abstract
Introduction Fluoride plays an important role in the control of dental caries, and currently new dentifrices are being associated with natural products. Objective This study aimed to evaluate the availability of fluoride in saliva samples after using a dentifrice incorporated with Brazilian red propolis (BRP, INPI Patent no. BR1020170110974) and to compare it to a conventional fluoridated dentifrice in healthy participants. Methods This study was conducted implementing a double-blind, randomized, controlled, and crossover design. Saliva samples of participants were collected at the following time points: 0 at baseline and 5, 15, 30, 45, and 60 minutes after brushing with each dentifrice. Salivary fluoride concentrations showed no statistically significant difference when comparing the two treatments (p > 0.05). All available fluoride concentrations in saliva decreased after one hour, with no significant difference between BRP and conventional fluoridated dentifrice treatment samples (p > 0.05). Results The results showed that there was no difference between the analyzed fluoride concentrations 1 hour after brushing with the different dentifrices. Conclusions The results of this study suggest that the propolis incorporated in the dentifrice did not interfere with the kinetics and bioavailability of the fluoride ion in saliva samples, enabling its integration with the pharmaceutical formula and thereby promoting its anti-inflammatory and antimicrobial benefits without compromising the anticaries activity of the formulation.
Highlights
Fluoride plays an important role in the control of dental caries, and currently new dentifrices are being associated with natural products
E Total fluoride (TF), total soluble fluoride (TSF), and ionic fluoride (IF) concentrations in saliva significantly increased after brushing with conventional dentifrice, Brazilian red propolis (BRP) dentifrice, or control, reaching maximum concentrations in the first five minutes of the test and gradually decreasing over time, with no significant difference between the fluoride forms within these groups (p > 0.05)
It was observed that the concentrations of the fluoride forms for the BRP dentifrice varied from 0.19 to 7.64 and from 0.33 to 8.26 for the conventional fluoride dentifrice, with no statistically significant difference between the three groups (p 0.52, Friedman test)
Summary
Fluoride plays an important role in the control of dental caries, and currently new dentifrices are being associated with natural products. All available fluoride concentrations in saliva decreased after one hour, with no significant difference between BRP and conventional fluoridated dentifrice treatment samples (p > 0.05). E effect of fluoride on the control of dental caries is local and depends on constant maintenance in the oral cavity so that it can interfere with the process of developing lesions [2]. It is considered the most important therapeutic substance added to dentifrices, considerably increasing the effect of mechanical toothbrushing on the control of tooth decay [3]. Compounds of natural origin have been used in formulations in searching for products with therapeutic activity, low cost or local availability, biocompatibility, and (reputedly) lower toxicity [5]
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
