Abstract
Salivary duct carcinoma (SDC) is an uncommon and highly aggressive tumor associated with high morbidity and mortality. According to the World Health Organization, it is an extremely rare malignancy with an estimated incidence of 1-1.2 in 1,000,000 patients. Standard treatment for SDC is wide surgical resection along with lymph node dissection followed by adjuvant radiation therapy. The role of adjuvant chemotherapy is not known. In this report, we present three cases of SDC. A 71-year-old female with T1N0M0 disease was treated with total parotidectomy, ipsilateral neck dissection, and adjuvant radiotherapy without evidence of disease recurrence at 5 months. The second is a 59-year-old female with TXN1M0 disease who was treated with total parotidectomy with ipsilateral level I-IV neck dissection and adjuvant radiotherapy without evidence of disease occurrence at 21 months. The third case is a 79-year-old male with widely metastatic disease, including brain metastases, treated with cranial irradiation, leuprolide, and lapatinib who remains under home hospice care.
Highlights
Salivary duct carcinoma (SDC) is a rare, highly aggressive malignancy
The mainstay of treatment for SDC is wide surgical resection along with lymph node dissection followed by adjuvant radiation therapy
Kleinsasser et al described salivary duct carcinoma (SDC) in 1968 as a salivary malignancy that histologically resembles in situ and invasive ductal carcinoma of the breast [2, 5]
Summary
Salivary duct carcinoma (SDC) is a rare, highly aggressive malignancy. The term SDC describes the malignancy that histologically resembles in situ and invasive ductal carcinoma of the breast. SDC is an extremely rare malignancy with an estimated incidence of 1-1.2 in 1,000,000 patients, with a higher prevalence in men [3]. It is often diagnosed at an advanced stage as it metastasizes early to regional lymph nodes and distant sites. Most clinical studies of SDC in the literature are institution-based retrospective cohort studies. This malignancy poses a challenge for physicians to provide education and information to the patients regarding the overall prognosis and treatment options given the absence of consensus guidelines. We describe three cases of SDC recently encountered in our institution
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